doi:10.1148/rg.2019180200
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Both legal authorities and medical ethics counsel restraint
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The effects were modest and the clinical relevance uncertain, but they highlight that GHS-R1a signaling extends beyond the somatotroph axis and has the potential to influence multiple endocrine systems
More importantly, the hazard ratio for major adverse cardiovascular events (including cardiovascular death, myocardial infarction, stroke, or hospitalization for unstable angina) for the pooled tirzepatide groups versus glargine was 0.74 (95% CI 0.511.08), suggesting no increased cardiovascular risk with tirzepatide compared to insulin glargine